Industrial Safety and Health Act（Act No. 57 of 1972）.

The purpose of this Act is to ensure workers' safety and health in the workplace and to facilitate the creation of comfortable work environments, by advancing comprehensive and systematic measures related to industrial injury prevention.
The Minister of Health, Labour and Welfare must formulate an Industrial Injury Prevention Plan (Art. 6). The necessary measures must be taken by an employer to prevent the health impairments as prescribed in Article 22, and to prevent the dangers as prescribed in Article 20, including dangers due to substances of an explosive nature, substances of a combustible nature, and substances of an inflammable nature. A person seeking to manufacture machinery or other such equipment set forth in Appended Table 1 as necessitating particularly dangerous work operations, and also specified by Cabinet Order, must obtain permission from the Director of the Prefectural Labour Bureau in advance (Art. 37). Articles 55 to 58 provide for dangerous substances and hazardous substances. A person seeking to manufacture substances that could cause significant impairments of workers' health, such as dichlorobenzidine, preparations containing dichlorobenzidine, and that are specified by Cabinet Order must obtain permission in advance.